WM-3835 |
WM-3835 : Inhibitor of KAT7
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| KAT7 |
|
|
Inhibitor
Concentration in cells may need to be higher than 3 uM in certain experiments, and users should confirm sufficient efficacy in their models.
3 uM
Selectivity
In Vitro Selectivity Assessment
KAT6A
Gene ID: Q92794
Organism: Homo sapiens
Family: MYST (SAS/MOZ) family
Potency: IC50 - 17 nM
Selectivity Assessment Description:
biochemical assay and SPR (Kd = 7 nM)
Potency Cellular
In Vitro
KAT7
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? No
DOI Reference: 10.1038/s41586-019-1835-6
In Vivo Validations
Mouse
Dose: 100 mg/Kg BID
Route of delivery:
Oral
Plasma half life:
5 min
Systemic clearance:
~400 uL/min/mg protein
Fb :
99.8%
DOI Reference: 10.1038/s41586-019-1835-6
Negative Control Compounds
Chemical Information
| Molecular Formula | C20H17FN2O4S |
| SMILEs | Cc1cc(-c2ccccc2)cc(C(=O)NNS(=O)(=O)c2cccc(O)c2)c1F |
| InChI | InChI=1S/C20H17FN2O4S/c1-13-10-15(14-6-3-2-4-7-14)11-18(19(13)21)20(25)22-23-28(26,27)17-9-5-8-16(24)12-17/h2-12,23-24H,1H3,(H,22,25) |
| Molecular weight | 400.09 Da |
| AlogP | 3.13002 |
| HBond acceptors | 6 |
| HBond donors | 3 |
| Atoms | 45 |
Vendors
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