VU69 |
VU69 : Inhibitor of PLD1
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| PLD1 |
|
|
Inhibitor
up to 200 nM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
In cells, IC50 for PLD2 =1,800 nM (HEK293-gfpPLD2 PLD activity)
Selectivity within target family: 20 ...
Potency Cellular
In Vitro
PLD1
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1038/nchembio.140
Chemical Information
| Molecular Formula | C26H27ClN4O2 |
| SMILEs | C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)NC(=O)c1ccc2ccccc2c1 |
| InChI | InChI=1S/C26H27ClN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1 |
| Molecular weight | 462.18 Da |
| AlogP | 0.0 |
| HBond acceptors | 6 |
| HBond donors | 2 |
| Atoms | 60 |
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