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Vimirogant | Inhibitor of RORC
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
RORC
  • IC50:3.7 nM
  • IC50:17 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
more than 1000-fold selectivity against other ROR isoforms
In Cell Selectivity Assessment
Selectivity Assessment Description:
inhibit hERG by 45.4% at 3 μM

Potency
Cellular
In Vitro

RORC

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

In Vivo Validations

Mouse, Rat, Dog
Dose: 15-100 mg/Kg
Route of delivery: Oral
Plasma half life: 6 (R), 15 (D) h

Reference: --

Orthogonal Probes def

T0901317

Chemical Information

Molecular Formula C27H35F3N4O3S
SMILEs CCS(=O)(=O)c1ccc(CNC(=O)c2cnc3c(c2)CN(C[C@H]2CC[C@H](C(F)(F)F)CC2)[C@H]3C(C)C)nc1
InChI InChI=1S/C27H35F3N4O3S/c1-4-38(36,37)23-10-9-22(31-14-23)13-33-26(35)19-11-20-16-34(25(17(2)3)24(20)32-12-19)15-18-5-7-21(8-6-18)27(28,29)30/h9-12,14,17-18,21,25H,4-8,13,15-16H2,1-3H3,(H,33,35)/t18-,21-,25-/m0/s1
Molecular weight 552.24 Da
AlogP 5.0816
HBond acceptors 7
HBond donors 1
Atoms 73

References

Publications

    Cross References

    canSARChEMBLBindingDBPDBe (Protein Data Bank Europe)

    Vendors

    Note: This is not an exhaustive list and does not indicate endorsement by the portal.

    Expert Reviews

    by SERP
    (on 21 Jun 2021 )
    Cellular Use Rating
    In Model Organisms
    Vimirogant is a RORgt inverse agonist with potent cellular activity and more than 1000-fold selectivity over RORa and RORb. It has been dosed orally in man in phase I and phase II clinical studies....
    by SERP
    (on 7 Jul 2021 )
    Cellular Use Rating
    In Model Organisms
    This compound is an inhibitor of RORc, that was developed as a therapeutic for autoimmune diseases by Vitae Pharmaceuticals (now Allergan Pharmaceutical). The compound is reported to induce the expression...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria