Chemical Probes logo
USP30inh | USP30inh : Irreversible Inhibitor of USP30
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
USP30
  • IC50:2.5 nM
  • IC50:160 nM
irreversible
200 nM
up to 1 uM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
The endogenous cellular selectivity of USP30inh for USP30 inhibition was confirmed using activity-ba ...

Potency
Cellular
In Vitro

USP30

Mode of Action: irreversible

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1016/j.mcpro.2023.100609

Chemical Information

Molecular Formula C26H28FN3O4S
SMILEs CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccc(F)cc2)cc1
InChI InChI=1S/C26H28FN3O4S/c1-26(2,3)30-35(33,34)22-15-13-21(14-16-22)28-25(32)23(17-18-7-5-4-6-8-18)29-24(31)19-9-11-20(27)12-10-19/h4-16,23,30H,17H2,1-3H3,(H,28,32)(H,29,31)/t23-/m0/s1
Molecular weight 497.18 Da
AlogP 3.8823000000000025
HBond acceptors 7
HBond donors 3
Atoms 63

References

Publications

Cross References

canSARChEMBLBindingDB

Expert Reviews

by SERP
(on 26 Jun 2025 )
Cellular Use Rating
This is a highly potent USP30 inhibitor that has been screened across a wide panel of deubiquitinases and found to be highly selective within this family. Furthermore, it seems to be able to phenocopy...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria