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UNC8732 | UNC8732 : Degrader (PROTAC) of NSD
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NSD2
  • Kd:71 ± 4 nM
  • DC50:60 ± 30 nM
  • Dmax:97 ± 2%
Degrader (PROTAC)
up to 2 uM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
Global proteomic of U2OS cells was used to assess selectivity up to 10 uM for both UNC8732 and UNC88 ...

Potency
Cellular
In Vitro

NSD2

Mode of Action: Degrader (PROTAC)

Structure-Activity-Relationship data available? No

DOI Reference: 10.1038/s41589-024-01660-y

Negative Control Compounds

canSAR7437549
Notes: UNC8884 (cpd 5), substantially reduces NSD2 binding and, does not promote NSD2 degradation

Chemical Information

Molecular Formula C35H39N5O5
SMILEs NCCCCCC(=O)N1CCc2cc(NC(=O)c3ccc(CN(C(=O)c4ccc5c(c4)OCC(=O)N5)C4CC4)cc3)ccc2C1
InChI InChI=1S/C35H39N5O5/c36-16-3-1-2-4-33(42)39-17-15-25-18-28(11-9-27(25)21-39)37-34(43)24-7-5-23(6-8-24)20-40(29-12-13-29)35(44)26-10-14-30-31(19-26)45-22-32(41)38-30/h5-11,14,18-19,29H,1-4,12-13,15-17,20-22,36H2,(H,37,43)(H,38,41)
Molecular weight 609.30 Da
AlogP 4.478400000000003
HBond acceptors 10
HBond donors 4
Atoms 84

Expert Reviews

by SERP
(on 21 Aug 2025 )
Cellular Use Rating
UNC8732 is a prodrug with the requirement of 10% FBS for its full activity. NC8732 is not active in FBS-low medium such as Opti-MEM.
by SERP+
(on 6 Feb 2026 )
Cellular Use Rating
UNC8732 is a well-validated PROTAC that acts as prodrug. It requires metabolism by amine oxidases (present in FBS) to convert its primary amine into an aldehyde. Therefore, this probe must be used in media...
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