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UNC6852 | UNC6852 : Degrader (PROTAC) of EED and PRC complex
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
EED
  • IC50:247 nM
  • EC50:790 nM
  • DC50:610 nM
  • EC50:3400 nM
  • Dmax:92%
  • Dmax:94%
  • Activity:10 µM
EZH2
    • DC50:300 nM
    • DC50:670 nM
    • Dmax:64%
    • Dmax:96%
    SUZ12
      • DC50:590 nM
      • Dmax:22%
      • Dmax:82%
      Degrader (PROTAC)
      10 µM to reliably degrade the target
      up to 10 uM

      Selectivity

      In Vitro Selectivity Assessment
      Potency Assay Off-Target:
      Global proteomics experiments using tandem mass tag quantification comparing HeLa cells treated with ...
      Selectivity Assessment Description:
      EED and EZH2 were selectively degraded by UNC6852 within the proteome. Modest SUZ12 degradation (21% ...

      Potency
      Cellular
      In Vitro

      EED

      Mode of Action: Degrader (PROTAC)

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1016/j.chembiol.2019.11.006

      EZH2

      Mode of Action: Degrader (PROTAC)

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1016/j.chembiol.2019.11.006

      SUZ12

      Mode of Action: Degrader (PROTAC)

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1016/j.chembiol.2019.11.006

      Negative Control Compounds

      UNC7043
      SMILES: Cc1c(c2ccc(CNC([C@@H]3C[C@@H](CN3C([C@H](C(C)(C)C)NC(CCCNC(c4ccc(c(cnc5NCc6occc6)c7n5cnn7)cc4)=O)=O)=O)O)=O)cc2)scn1

      Chemical Information

      Molecular Formula C43H48N10O6S
      SMILEs Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCNC(=O)c2ccc(-c3cnc(NCc4ccco4)n4cnnc34)cc2)C(C)(C)C)cc1
      InChI InChI=1S/C43H48N10O6S/c1-26-36(60-25-48-26)29-11-9-27(10-12-29)20-45-40(57)34-19-31(54)23-52(34)41(58)37(43(2,3)4)50-35(55)8-5-17-44-39(56)30-15-13-28(14-16-30)33-22-47-42(53-24-49-51-38(33)53)46-21-32-7-6-18-59-32/h6-7,9-16,18,22,24-25,31,34,37,54H,5,8,17,19-21,23H2,1-4H3,(H,44,56)(H,45,57)(H,46,47)(H,50,55)/t31-,34+,37-/m1/s1
      Molecular weight 832.35 Da
      AlogP 0.0
      HBond acceptors 16
      HBond donors 5
      Atoms 108

      Vendors

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      Expert Reviews

      by SERP
      (on 16 Mar 2022)
      Cellular Use Rating
      Degradation of target proteins is dependent on cellular VHL expression. The activity may be lower / recommended cellular concentration higher in cells with low VHL expression (e.g., platelets). Degradation...
      by SERP
      (on 10 Apr 2022)
      Cellular Use Rating
      (The reviewer did not leave any public comments)
      by SERP+
      (on 6 Feb 2026)
      Cellular Use Rating
      UNC6852 is an EED-targeted, VHL-recruiting bivalent chemical degrader. Degradation of EED leads to co-degradation of the other core PRC2 subunit EZH2, with more modest degradation of SUZ12. UNC6852 was...
      Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria