Chemical Probes logo
UNC0642 | UNC0642 : Inhibitor of EHMT2 and EHMT1
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
EHMT2
  • Ki:3.7 nM
  • IC 50:110 nM
EHMT1
  • IC 50:<2.5 nM
  • IC 50:110 nM
Inhibitor
100 nM - 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
UNC0642 was 2,000-fold selective for the targets over EZH2/PRC2 and 20,000-fold over 15 other protei ...
Selectivity Assessment Description:
UNC0642 was 2,000-fold selective for the targets over EZH2/PRC2 and 20,000-fold over 15 other prote ...

Potency
Cellular
In Vitro

EHMT2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/jm401480r

EHMT1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/jm401480r

In Vivo Validations

Mouse
Dose: 5 mg/kg
Route of delivery: Intraperitoneal
Organ of interest (O): brain

DOI Reference: 10.1021/jm401480r

Orthogonal Probes def

UNC0638
BIX-01294
A-366

Chemical Information

Molecular Formula C29H44F2N6O2
SMILEs COc1cc2c(NC3CCN(C(C)C)CC3)nc(N3CCC(F)(F)CC3)nc2cc1OCCCN1CCCC1
InChI InChI=1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34)
Molecular weight 546.35 Da
AlogP 5.0233
HBond acceptors 8
HBond donors 1
Atoms 83

References

Publications

Cross References

canSARChEMBLBindingDBGDSC1

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the portal.

Expert Reviews

by SERP
(on 17 Oct 2016 )
Cellular Use Rating
In Model Organisms
UNC0642 potently and specifically inhibits G9a and GLP compared with a wide range of pharmacologically important proteins (except for the histamine H3 receptor) in cell-free assays. Importantly, the...
by SERP
(on 21 Jan 2017 )
Cellular Use Rating
In Model Organisms
The in vitro potency and selectivity against other family members is good. The margin between concentrations that yield a functional effect and cellular toxicity was determined and is at least 80-fold....
by SERP
(on 18 Jun 2017 )
Cellular Use Rating
In Model Organisms
This is a well characterised probe with dual activity against the related targets GLP and G9a. The probe has been evaluated for selectivity against a variety of off-targets including kinases, GPCRs,...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria