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UCPH-101 | UCPH-101 : Inhibitor of SLC1A3
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
SLC1A3
    • IC50:120 nM
    • IC50:660 nM
    • Kd:340 nM
    Inhibitor
    up to 10 uM

    Selectivity

    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    Selectivity within target family: The compound did not display any significant inhibition of the Glu ...
    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    The functional properties of UCPH-101 were characterized by patch-clamp electrophysiology on tsA201 ...

    Potency
    Cellular
    In Vitro

    SLC1A3

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1021/jm8013458

    Chemical Information

    Molecular Formula C27H22N2O3
    InChI InChI=1S/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,25H,13-14,29H2,1H3
    Molecular weight 422.16 Da
    AlogP 0.0
    HBond acceptors 5
    HBond donors 2
    Atoms 54

    References

    Publications

    Cross References

    canSARChEMBL

    Expert Reviews

    by SERP
    (on 6 Mar 2025 )
    Cellular Use Rating
    UCPH-101 is an inhibitor of EAAT1/SLC1A3. Humans have five members in this excitatory amino acid transporter family (EAAT1-5). UCPH-101 shows >450-fold selectivity over human EAAT2 and EAAT3. Selectivity...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria