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U18666A | Inhibitor of NPC1
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NPC1
    • Ki:30 nM
    Inhibitor
    0.1-1 uM

    Selectivity

    Potency
    Cellular
    In Vitro

    NPC1

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? No

    In Vivo Validations

    Rat
    Dose: 10 mg/Kg
    Route of delivery: Subcutaneous

    Reference: --

    Negative Control Compounds

    Compound A

    Chemical Information

    Molecular Formula C25H42ClNO2
    SMILEs CCN(CC)CCO[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]32)C1.Cl
    InChI InChI=1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-11-13-24(3)18(17-19)7-8-20-21-9-10-23(27)25(21,4)14-12-22(20)24;/h7,19-22H,5-6,8-17H2,1-4H3;1H/t19-,20-,21-,22-,24-,25-;/m0./s1
    Molecular weight 423.29 Da
    AlogP 5.667100000000007
    HBond acceptors 3
    HBond donors --
    Atoms 71

    References

    Publications

      Cross References

      Vendors

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      Expert Reviews

      by SERP
      (on 13 Mar 2021 )
      Cellular Use Rating
      In Model Organisms
      More data is needed for this compound to judge it as a probe. No panel data is provided neither within target family nor outside. Crosslinking experiments have identified the proposed target. Analogues...
      by SERP
      (on 13 Mar 2021 )
      Cellular Use Rating
      In Model Organisms
      With very little characterization, it is difficult to judge the quality of this compound. There is no selectivity screening and only a single on-target cellular assay. The data has not been validated...
      by SERP
      (on 20 Mar 2021 )
      Cellular Use Rating
      In Model Organisms
      U18666A is a chemical probe for NPC1 that transports cholesterol from the lysosomal membrane. In cells U18666A inhibits cholesterol transesterification and SREBP2 processing at nM concentrations. U18666A...
      Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria