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TUG-891 | Agonist of FFAR4
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
FFAR4
    • EC50:43.6 nM
    Agonist
    up to 10 uM

    Selectivity

    In Cell Selectivity Assessment
    Selectivity Assessment Description:
    Selective over free fatty acid receptors (pEC50 = 4.19 for FFA1; displays no activity at FFA2 or ...

    Potency
    Cellular
    In Vitro

    FFAR4

    Mode of Action: Agonist

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1021/jm300215x

    In Vivo Validations

    Mouse
    Dose:
    Route of delivery: Oral

    Reference: --

    Orthogonal Probes def

    GPR120-IN-1

    Chemical Information

    Molecular Formula C23H21FO3
    SMILEs Cc1ccc(-c2ccc(F)cc2COc2ccc(CCC(=O)O)cc2)cc1
    InChI InChI=1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26)
    Molecular weight 364.15 Da
    AlogP 5.397320000000004
    HBond acceptors 3
    HBond donors 1
    Atoms 48

    References

    Publications

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    Expert Reviews

    No SERP comments found for TUG-891

    Probe TUG-891 is in the process of SERP review.

    Please continue to check back for new reviews and commentary.