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TUG-469 | Agonist of FFAR1
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
FFAR1
    • EC50:19 nM
    Agonist
    up to 1 uM

    Selectivity

    In Cell Selectivity Assessment
    Selectivity Assessment Description:
    No significant activity on the related receptors FFA2 (GPR43) or FFA3 (GPR41). No significant ago ...

    Potency
    Cellular
    In Vitro

    FFAR1

    Mode of Action: Agonist

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1021/ml100106c

    In Vivo Validations

    Mouse
    Dose: 10 mg/Kg
    Route of delivery: Oral

    DOI Reference: 10.1021/ml100106c

    Orthogonal Probes def

    TUG-469
    Fasiglifam
    AMG-837

    Chemical Information

    Molecular Formula C23H23NO2
    SMILEs Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1
    InChI InChI=1S/C23H23NO2/c1-17-5-2-3-8-22(17)20-7-4-6-19(15-20)16-24-21-12-9-18(10-13-21)11-14-23(25)26/h2-10,12-13,15,24H,11,14,16H2,1H3,(H,25,26)
    Molecular weight 345.17 Da
    AlogP 5.291320000000004
    HBond acceptors 3
    HBond donors 2
    Atoms 49

    Vendors

    Note: This is not an exhaustive list and does not indicate endorsement by the portal.

    Expert Reviews

    by SERP
    (on 26 Feb 2021)
    Cellular Use Rating
    In Model Organisms
    (The reviewer did not leave any public comments)
    by SERP
    (on 14 Apr 2021)
    Cellular Use Rating
    In Model Organisms
    (The reviewer did not leave any public comments)
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria