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TUG-469 | Agonist of FFAR1
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
FFAR1
    • EC50:19 nM
    Agonist
    up to 1 uM

    Selectivity

    In Cell Selectivity Assessment
    Selectivity Assessment Description:
    No significant activity on the related receptors FFA2 (GPR43) or FFA3 (GPR41). No significant ago ...

    Potency
    Cellular
    In Vitro

    FFAR1

    Mode of Action: Agonist

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1021/ml100106c

    In Vivo Validations

    Mouse
    Dose: 10 mg/Kg
    Route of delivery: Oral

    DOI Reference: 10.1021/ml100106c

    Orthogonal Probes def

    TUG-469
    Fasiglifam
    AMG-837

    Chemical Information

    Molecular Formula C23H23NO2
    SMILEs Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1
    InChI InChI=1S/C23H23NO2/c1-17-5-2-3-8-22(17)20-7-4-6-19(15-20)16-24-21-12-9-18(10-13-21)11-14-23(25)26/h2-10,12-13,15,24H,11,14,16H2,1H3,(H,25,26)
    Molecular weight 345.17 Da
    AlogP 5.291320000000004
    HBond acceptors 3
    HBond donors 2
    Atoms 49

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    Expert Reviews

    by SERP
    (on 26 Feb 2021 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
    by SERP
    (on 14 Apr 2021 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria