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TTT20171 | Inhibitor of SDHC
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
SDHC
  • IC50:3.3 nM
  • IC50:5400 nM
Inhibitor
Up to 2 uM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50 - Mitochondrial Complex I: >10,000 nM

Potency Assay Off-Target:
Spectrophotometric assay in frozen-thawed mouse heart mitochondria.

Potency
Cellular
In Vitro

SDHC

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

Negative Control Compounds

(rac)-2,3-dimethoxy-5-(1-methoxyhexyl)pyridin-4-ol (Compound 24)

Chemical Information

Molecular Formula C20H33NO5
SMILEs CCCCCCCCCCCCC(=O)c1c(O)c(OC)c(OC)[nH]c1=O
InChI InChI=1S/C20H33NO5/c1-4-5-6-7-8-9-10-11-12-13-14-15(22)16-17(23)18(25-2)20(26-3)21-19(16)24/h4-14H2,1-3H3,(H2,21,23,24)
Molecular weight 367.24 Da
AlogP 4.591400000000003
HBond acceptors 6
HBond donors 2
Atoms 59

References

Publications

    Cross References

    canSAR

    Expert Reviews

    by SERP
    (on 18 Aug 2017 )
    Cellular Use Rating
    In Model Organisms
    TTT20171 (compound 16k Wang et al., ChemMedChem 2017) displays nanomolar inhibition of CII but lacks cellular potency. In cell assays, the most sensitive cells (22Rv1 prostate cancer cells) are inhibited...
    by SERP
    (on 11 Nov 2020 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
    by SERP
    (on 24 Apr 2023 )
    Cellular Use Rating
    This work demonstrates a potent in vitro inhibitor of SDH activity against isolated mitochondria (IC50 < 10nM). While cellular anti-proliferative and mitochondrial functional data are presented, there...
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