Chemical Probes logo
TTBK1-IN-2 | TTBK1-IN-2 : Inhibitor of TTBK1
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
TTBK1
  • IC50:240 nM
Inhibitor
up to 5 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Selective against TTBK2 with IC50 4220 nM. TTBK1-IN-2 was screened at a fixed concentration of 10 μM ...

Potency
Cellular
In Vitro

TTBK1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.1c01942

In Vivo Validations

Mouse
Dose: 5 mg/Kg
Route of delivery: Intraperitoneal
Plasma half life: 3.75 (plasma), 3.46 (brain) h
Cmax: 1429.08 (plasma), 4174.12 (brain) ng/mL
Tmax: 1.0 h (brain, plasma)
Area Under the Curve:: 5958.82 (plasma), 15652.49 (brain) h·ng/mL

DOI Reference: 10.1021/acs.jmedchem.1c01942

Dose: 10 mg/Kg
Route of delivery: Oral
Plasma half life: 3.30 (plasma), 3.40 (brain) h
Cmax: 2265.04 (plasma), 4923.89 (brain) ng/mL
Tmax: 2.0 h (plasma, brain)
Area Under the Curve:: 18406.33 (plasma), 49172.57 (brain) h·ng/mL

DOI Reference: 10.1021/acs.jmedchem.1c01942

Chemical Information

Molecular Formula C18H13ClN4O
SMILEs Clc1ccc(Oc2ccc(Nc3ncnc4[nH]ccc34)cc2)cc1
InChI InChI=1S/C18H13ClN4O/c19-12-1-5-14(6-2-12)24-15-7-3-13(4-8-15)23-18-16-9-10-20-17(16)21-11-22-18/h1-11H,(H2,20,21,22,23)
Molecular weight 336.08 Da
AlogP 0.0
HBond acceptors 5
HBond donors 2
Atoms 37
PAINS * Yes

* This is an automated alert only, and may not necessarily indicate an issue with this probe. ( Learn more about PAINS )

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the portal.

Expert Reviews

No SERP comments found for TTBK1-IN-2

Probe TTBK1-IN-2 is in the process of SERP review.

Please continue to check back for new reviews and commentary.