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TRAM-34 | TRAM-34 : Inhibitor of KCNN4
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
KCNN4
    • Kd:20 nM
    • EC50:295-910 nM
    • Kd:22 nM
    Inhibitor
    up to 200 nM
    up to 5 uM

    Selectivity

    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    TRAM-34 was screened against a panel of 15 other channels. TRAM-34 is 200- to 1,500-fold less effect ...

    Potency
    Cellular
    In Vitro

    KCNN4

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1073/pnas.97.14.8151

    Chemical Information

    Molecular Formula C22H17ClN2
    SMILEs Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1
    InChI InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
    Molecular weight 344.11 Da
    AlogP 5.376700000000004
    HBond acceptors 2
    HBond donors --
    Atoms 42

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    Expert Reviews

    by SERP
    (on 7 Dec 2022 )
    Cellular Use Rating
    Results should be interpreted with caution and reference made to reported off-target activities against nonselective cation channels (doi: 10.1007/s00424-007-0232-4), several rodent and human cytochrome...
    by SERP
    (on 7 Dec 2022 )
    Cellular Use Rating
    TRAM-34 has been commercialized a blocker of KCa3.1for many years, considering vast family of channel and transporter proteins vs medium molecular size of TRAM-34, a thorough test of TRAM-34 against majority...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria