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TP-061 | TP-061 : Inhibitor of Brr2
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
SNRNP200
  • IC50:21 nM
  • Kd:22 nM
  • IC50:480 nM
  • IC50:660 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
TP-061 shows excellent selectivity over closely-related helicases, with no inhibition of eIF4A1, eIF ...

Potency
Cellular
In Vitro

SNRNP200

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1016/j.bmc.2017.07.017

Negative Control Compounds

canSAR136067
Notes: The enantiomer, TP-061N (cpd 32b), serves as an ideal negative control with IC50 of 84 mM in the ATPase assay.

Chemical Information

Molecular Formula C21H25FN4O2
SMILEs CC(C)C[C@@H]1C[C@H](C)[C@@]2(C(=O)Nc3ccc(F)cc32)N1C(=O)c1cn(C)cn1
InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m0/s1
Molecular weight 384.20 Da
AlogP 3.3035000000000014
HBond acceptors 6
HBond donors 1
Atoms 53

References

Publications

Cross References

Expert Reviews

No SERP comments found for TP-061

Probe TP-061 is in the process of SERP review.

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