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TH65 | TH65 : Inhibitor of HDAC10
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
HDAC10
  • Kd:630 nM
  • IC50:100 nM
  • EC50:250 nM
Inhibitor
up to 5 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Concentration- And Target-Dependent Selectivity (CATDS) score shows high selectivity for HDAC10 with ...

Potency
Cellular
In Vitro

HDAC10

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1038/s41589-022-01015-5

Chemical Information

Molecular Formula C21H18N2O4
SMILEs COc1ccc(C(=O)NO)cc1NC(=O)c1ccc(-c2ccccc2)cc1
InChI InChI=1S/C21H18N2O4/c1-27-19-12-11-17(21(25)23-26)13-18(19)22-20(24)16-9-7-15(8-10-16)14-5-3-2-4-6-14/h2-13,26H,1H3,(H,22,24)(H,23,25)
Molecular weight 362.13 Da
AlogP 3.733500000000002
HBond acceptors 6
HBond donors 3
Atoms 45

References

Publications

Cross References

Expert Reviews

by SERP
(on 4 Jul 2022 )
Cellular Use Rating
TH65 was recently discovered as a selective HDAC10 binder in a chemoproteomics study. Interestingly, TH65 was originally developed and promoted as a selective HDAC8 inhibitor, potent against both the S....
by SERP+
(on 17 Jun 2024 )
Cellular Use Rating
TH65 shows sufficient potency (600 nM), especially compared to the activities against other HDACs (higher than 30 uM). This is the most selective compound to date with only one off-target, which is however...
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