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TH5427 | Inhibitor of NUDT5
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NUDT5
  • IC50:29 nM
  • EC50:2100 nM
Inhibitor
up to 1.5 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Screened in a panel of NUDIX enzymes and other nucleotide phosphohydrolases: outside of NUDT5, ha ...
In Cell Selectivity Assessment
Selectivity Assessment Description:
SafetyScreen 44 and ExpresSDiversity kinase panels from Eurofins Cerep Panlabs.

Potency
Cellular
In Vitro

NUDT5

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1038/s41467-017-02293-7

Chemical Information

Molecular Formula C20H20Cl2N8O3
SMILEs Cn1c(=O)c2c(nc(N3CCNCC3)n2Cc2nnc(-c3ccc(Cl)c(Cl)c3)o2)n(C)c1=O
InChI InChI=1S/C20H20Cl2N8O3/c1-27-16-15(18(31)28(2)20(27)32)30(19(24-16)29-7-5-23-6-8-29)10-14-25-26-17(33-14)11-3-4-12(21)13(22)9-11/h3-4,9,23H,5-8,10H2,1-2H3
Molecular weight 490.10 Da
AlogP 1.2484000000000002
HBond acceptors 11
HBond donors 1
Atoms 53

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Expert Reviews

by SERP
(on 11 Jul 2020 )
Cellular Use Rating
TH5427 is potent and selective chemical probe for NUDT5, a NUDIX hydrolase enzyme that plays important roles in the metabolism of adenosine-5’-diphisphoribose (ADPR) metabolism and regulation of hormone...
by SERP
(on 26 Jul 2020 )
Cellular Use Rating
TH5427 showed 690-fold selectivity for NUDT5 over MTH1 in direct assay of ADP-ribose hydrolysis in vitro.
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