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TES-1025 | TES-1025 : Inhibitor of ACMSD
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
ACMSD
  • IC50:13 ± 3 nM
  • % in:40%
Inhibitor
5 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Activity on a panel of nuclear receptors: PXR, PPARs, LXR, VDR, GR, RXR, FXR, TR, was based on Alpha ...

Potency
Cellular
In Vitro

ACMSD

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.7b01254

In Vivo Validations

Mouse
Dose: 0.5 mg/Kg
Route of delivery: Intravenous
Plasma half life: 5.33 h
Systemic clearance: 0.78 mL/min/kg
Area Under the Curve:: 10700 h·ng/mL
Volume of Distribution at Steady-State: 0.273 L/Kg

DOI Reference: 10.1021/acs.jmedchem.7b01254

Dose: 5 mg/Kg
Route of delivery: Oral
Cmax: 2570 ng/mL
Tmax: 2.0 h
Area Under the Curve:: 12700 (heart), 19200 (liver), 36600 (kidney) h·ng/mL
Bioavailability: 12%

DOI Reference: 10.1021/acs.jmedchem.7b01254

Chemical Information

Molecular Formula C17H12N4O3S2
SMILEs N#Cc1c(-c2cccs2)nc(SCc2cccc(C(=O)NO)c2)[nH]c1=O
InChI InChI=1S/C17H12N4O3S2/c18-8-12-14(13-5-2-6-25-13)19-17(20-16(12)23)26-9-10-3-1-4-11(7-10)15(22)21-24/h1-7,24H,9H2,(H,21,22)(H,19,20,23)
Molecular weight 384.04 Da
AlogP 2.7813800000000004
HBond acceptors 7
HBond donors 3
Atoms 38
PAINS * Yes

* This is an automated alert only, and may not necessarily indicate an issue with this probe. ( Learn more about PAINS )

References

Publications

Cross References

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Expert Reviews

No SERP comments found for TES-1025

Probe TES-1025 is in the process of SERP review.

Please continue to check back for new reviews and commentary.