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TDI-11055 | TDI-11055 : Inhibitor of MLLT1
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MLLT1
  • Kd:120 nM
  • IC50:50 nM
  • IC50:100 nM
Inhibitor
up to 1 uM

Selectivity

Potency
Cellular
In Vitro

MLLT1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acsmedchemlett.4c00016

In Vivo Validations

Rat
Dose: 2 mg/Kg
Route of delivery: Intravenous
Plasma half life: 1.54 h
Systemic clearance: 108 mL/min/kg
Area Under the Curve:: 314 h*ng/mL
Volume of Distribution at Steady-State: 7.3 L/Kg

DOI Reference: 10.1021/acsmedchemlett.4c00016

Dose: 10 mg/Kg
Route of delivery: Oral
Bioavailability: 31%

DOI Reference: 10.1021/acsmedchemlett.4c00016

Chemical Information

Molecular Formula C22H24N6O
InChI InChI=1S/C22H24N6O/c1-14-4-3-7-28(14)13-18-9-16-11-23-21(10-19(16)25-18)26-22(29)15-5-6-20-17(8-15)12-24-27(20)2/h5-6,8-12,14,25H,3-4,7,13H2,1-2H3,(H,23,26,29)/t14-/m0/s1
Molecular weight 388.20 Da
AlogP 0.0
HBond acceptors 7
HBond donors 2
Atoms 53

References

Publications

Cross References

canSARChEMBL

Expert Reviews

by SERP
(on 10 Mar 2026 )
Cellular Use Rating
In Model Organisms
No target engagement data have been shown, just cell proliferation assays.
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