TDI-10229 |
TDI-10229 : Inhibitor of ADCY10
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| ADCY10 |
|
|
Inhibitor
up to 1 uM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
TDI-10229 did not show appreciable activity against a panel of 310 kinases and 46 other well-known d ...
Potency Cellular
In Vitro
ADCY10
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acsmedchemlett.1c00273
In Vivo Validations
Mouse
Dose: 20 mg/kg
Route of delivery:
Oral
Plasma half life:
3.95 h (MRT)
Cmax:
15.5 μM
Area Under the Curve::
94 μM·h
DOI Reference: 10.1021/acsmedchemlett.1c00273
Dose: 20 mg/Kg
Route of delivery:
Intraperitoneal
Plasma half life:
2.82 h (MRT)
Cmax:
45 μM
Area Under the Curve::
72 μM·h
DOI Reference: 10.1021/acsmedchemlett.1c00273
Negative Control Compounds
Chemical Information
| Molecular Formula | C16H16ClN5 |
| SMILEs | Cc1c(Cc2ccccc2)c(-c2cc(Cl)nc(N)n2)nn1C |
| InChI | InChI=1S/C16H16ClN5/c1-10-12(8-11-6-4-3-5-7-11)15(21-22(10)2)13-9-14(17)20-16(18)19-13/h3-7,9H,8H2,1-2H3,(H2,18,19,20) |
| Molecular weight | 313.11 Da |
| AlogP | 0.0 |
| HBond acceptors | 5 |
| HBond donors | 2 |
| Atoms | 38 |
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