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Talnetant | Talnetant : Competitive of TACR3
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
TACR3
  • Ki:1 nM
  • Kd:1.6 ± 0.53 nM
  • IC50:16.6 ± 1.6 nM
Competitive
up to 100 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Withing target family: Selectivity relative to other tachykinin receptors was assessed by competitiv ...

Potency
Cellular
In Vitro

TACR3

Mode of Action: Competitive

Structure-Activity-Relationship data available? Yes

PMID Reference: 9190866

In Vivo Validations

Rat
Dose: 6.9 ± 0.1 mg/Kg
Route of delivery: Intravenous
Plasma half life: 336 ± 40 min
Systemic clearance: 6.6 ± 1.2 mL/min/Kg
Area Under the Curve:: 0.89 ± 0.13 mg/ml/min

PMID Reference: 9190866

Dose: 8.0 ± 0.0 mg/Kg
Route of delivery: Oral
Plasma half life: 218 ± 36 min
Systemic clearance: 10.6 ± 1.4 mL/min/Kg
Cmax: 2.80 ± 0.54 ug/mL
Tmax: 180 min
Area Under the Curve:: 0.78 ± 0.09 mg/ml/min
Bioavailability: 62 ± 9%

PMID Reference: 9190866

Dog
Dose: 0.93 ± 0.02 mg/Kg
Route of delivery: Intravenous
Plasma half life: 404 ± 22 min
Systemic clearance: 0.58 ± 0.08 mL/min/Kg
Area Under the Curve:: 1.67 ± 0.24 mg/ml/min

PMID Reference: 9190866

Dose: 4.2 ± 0.2
Route of delivery: Oral
Plasma half life: 386 ± 92 min
Systemic clearance: 0.83 ± 0.12 mL/min/Kg
Cmax: 7.98 ± 0.07 ug/mL
Tmax: 60 min
Area Under the Curve:: 5.28 ± 0.94 mg/mL/min
Bioavailability: 71 ± 7%

PMID Reference: 9190866

Negative Control Compounds

SB-223411
Notes: Inactive enantiomer SB-223411 has in cell IC50 780 nM
SMILES: CC[C@H](c1ccccc1)NC(c(c(O)c(c2ccccc2)n3)c4c3cccc4)=O

Chemical Information

Molecular Formula C25H22N2O2
SMILEs CC[C@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1
InChI InChI=1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29)/t20-/m0/s1
Molecular weight 382.17 Da
AlogP 5.488500000000004
HBond acceptors 4
HBond donors 2
Atoms 51

References

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Expert Reviews

No SERP comments found for Talnetant

Probe Talnetant is in the process of SERP review.

Please continue to check back for new reviews and commentary.