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TAK-279 | TAK-279 : Inhibitor of TYK2
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
TYK2
  • Kd:0.0038 nM
  • IC50:1.7 nM
  • IC50:3.7 nM
Inhibitor
up to 100 nM in cells and 1 µM in whole blood
up to 10 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Compound 30 exhibits excellent overall kinome selectivity, with only 1 kinase inhibited at >50% in a ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
Compound 30 exhibited a higher level of functional selectivity in cellular and whole blood assays th ...

Potency
Cellular
In Vitro

TYK2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acs.jmedchem.3c00600

In Vivo Validations

Mouse
Dose: 10, 30, 100 mg/Kg
Route of delivery: Oral

DOI Reference: 10.1021/acs.jmedchem.3c00600

Rat
Dose: 10. 30, 100 mg/Kg
Route of delivery: Oral

DOI Reference: 10.1021/acs.jmedchem.3c00600

Chemical Information

Molecular Formula C23H24N8O3
SMILEs CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nc2c(C(=O)N[C@@H]3CC[C@H]3OC)cnn12
InChI InChI=1S/C23H24N8O3/c1-24-20-12-18(27-16-6-5-11-30(23(16)33)19-7-3-4-10-25-19)29-21-14(13-26-31(20)21)22(32)28-15-8-9-17(15)34-2/h3-7,10-13,15,17,24H,8-9H2,1-2H3,(H,27,29)(H,28,32)/t15-,17-/m1/s1
Molecular weight 460.20 Da
AlogP 0.0
HBond acceptors 11
HBond donors 3
Atoms 58

References

Publications

Cross References

canSARChEMBLBindingDBPDB

Vendors

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Expert Reviews

by SERP
(on 3 Nov 2024 )
Cellular Use Rating
In Model Organisms
The compound is an allosteric TYK2 inhibitor targeting the regulatory JH2 domain. It is highly selective against other JAK isoforms, within teh kinome, as well as in a broader off-target/safety panel....
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