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TAK-243 | Inhibitor of UBA1
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
UBA1
  • Kd:>0.75 nM
  • IC50:1 ± 0.2 nM
  • EC50:12-20 nM (48-72h)
Inhibitor
0.01, 0.10 or 1.00 μM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
TAK-243 has significant biochemical inhibitory activity against closely related E1 ubiquitin-like ...

Potency
Cellular
In Vitro

UBA1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1038/nm.4474

In Vivo Validations

Mouse
Dose: 12.5, 18.8, 25 mg/Kg
Route of delivery: Intravenous
Plasma half life: 17.4-20.6 h
Systemic clearance: 4.99-3.89 L/h/Kg

DOI Reference: 10.1038/nm.4474

Orthogonal Probes def

ABPA3

Chemical Information

Molecular Formula C19H20F3N5O5S2
SMILEs NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(-c4cccc(SC(F)(F)F)c4)nn23)[C@H](O)[C@@H]1O
InChI InChI=1S/C19H20F3N5O5S2/c20-19(21,22)33-12-3-1-2-10(6-12)13-8-16-24-5-4-15(27(16)26-13)25-14-7-11(17(28)18(14)29)9-32-34(23,30)31/h1-6,8,11,14,17-18,25,28-29H,7,9H2,(H2,23,30,31)/t11-,14-,17-,18+/m1/s1
Molecular weight 519.09 Da
AlogP 0.0
HBond acceptors 10
HBond donors 5
Atoms 54

References

Publications

Cross References

canSARChEMBLBindingDBPDBPubMed

Vendors

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Expert Reviews

by SERP
(on 20 May 2021 )
Cellular Use Rating
In Model Organisms
TAK-243 is a potent inhibitor of UAE which demonstrates complete inhibition of cellular ubiquitylation and sub-micromolar anti-proliferative activity against multiple cancer cell lines. Robust antitumor...
by SERP
(on 11 Jun 2021 )
Cellular Use Rating
In Model Organisms
TAK-243 is a potent inhibitor of UBA1 with cellular activities consistent with the proposed mechanism of action. TAK-243 shows anti-tumor activity in mouse xenograft studies at doses at or below the...
by SERP
(on 31 May 2023 )
Cellular Use Rating
In Model Organisms
( The reviewer did not leave any comments )
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