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T863 | T863 : Inhibitor of DGAT1
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
DGAT1
  • IC50:15 nM
  • IC50:4 nM
Inhibitor
up to 100 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Selective against DGAT2: 3.7 %inhibition @ 10 uM compound and ACAT-1 IC50 = 12000 nM

Potency
Cellular
In Vitro

DGAT1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/jm801507v

In Vivo Validations

Rat
Dose: 1-3 mg/Kg
Route of delivery: Intravenous, Oral
Plasma half life: 3.0 (IV), 5.6 (PO) h
Systemic clearance: 5.2 mL/min/kg
Bioavailability: 100%
Volume of Distribution at Steady-State: 0.69 L/Kg

DOI Reference: 10.1021/jm801507v

Dog
Dose: 1-3 mg/Kg
Route of delivery: Intravenous, Oral
Plasma half life: 3.9 (IV), 2.8 (PO) h
Systemic clearance: 12 mL/min/kg
Bioavailability: >100%
Volume of Distribution at Steady-State: 2.0 L/Kg

DOI Reference: 10.1021/jm801507v

Chemical Information

Molecular Formula C22H26N4O3
SMILEs CC1(C)Oc2ncnc(N)c2N=C1c1ccc([C@H]2CC[C@H](CC(=O)O)CC2)cc1
InChI InChI=1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
Molecular weight 394.20 Da
AlogP 4.099100000000003
HBond acceptors 7
HBond donors 3
Atoms 55

References

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Expert Reviews

by SERP
(on 14 Jun 2022 )
Cellular Use Rating
In Model Organisms
Caution should be taken that the reported bioavailability is based on the acyl glucuronide metabolite and not the parent compound.
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