T-690 |
T-690 : Inhibitor of UGCG
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download
Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| UGCG |
|
|
Inhibitor
up to 1 uM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
SAFETYscan (DiscoverX (Eurofins) 47 targets at 10 µM): 44 target > 10 µM; HTR1B (EC50 = 1.5 μM), nAC ...
Potency Cellular
In Vitro
UGCG
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acs.jmedchem.1c02078
In Vivo Validations
Mouse
Dose: 0.5 mg/Kg
Route of delivery:
Intravenous
Plasma half life:
1.03 h (MRT)
Systemic clearance:
2022 mL/h/Kg
Volume of Distribution at Steady-State:
1974 L/Kg
DOI Reference: 10.1021/acs.jmedchem.1c02078
Dose: 5 mg/Kg
Route of delivery:
Oral
Plasma half life:
1.91 h (MRT)
Cmax:
416 ng/mL
Area Under the Curve::
829 ng*h/mL
Fb :
31%
DOI Reference: 10.1021/acs.jmedchem.1c02078
Chemical Information
| Molecular Formula | C22H20F3N3O4 |
| SMILEs | CC(C)(O)c1ccc(NC(=O)c2ccnn(-c3ccccc3OCC(F)(F)F)c2=O)cc1 |
| InChI | InChI=1S/C22H20F3N3O4/c1-21(2,31)14-7-9-15(10-8-14)27-19(29)16-11-12-26-28(20(16)30)17-5-3-4-6-18(17)32-13-22(23,24)25/h3-12,31H,13H2,1-2H3,(H,27,29) |
| Molecular weight | 447.14 Da |
| AlogP | 0.0 |
| HBond acceptors | 7 |
| HBond donors | 2 |
| Atoms | 52 |
Vendors
Note: This is not an exhaustive list and does not indicate endorsement by the portal.