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T-26c | T-26c : Inhibitor of MMP13
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MMP13
  • IC50:0.0069 nM
Inhibitor
10-100 nM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50 - MMP2: 18 nM, MMP10: 160 nM, MMP3: 600 nM, MMP8: 780 nM

Potency Assay Off-Target:
MMP1, MMP7, MMP9, MMP14, TACE > 10,000 nM

Potency
Cellular
In Vitro

MMP13

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

In Vivo Validations

Guinea pig (male)
Dose: 10 mg/kg (oral); 1 mg/kg (IV)
Route of delivery: Intravenous, Oral
Systemic clearance: 431 mL/h/kg (IV)

Reference: --

Negative Control Compounds

T-26f (5-((benzyl(methyl)amino)methyl)-N-(3-methoxybenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide)

Chemical Information

Molecular Formula C24H21N3O6S
SMILEs COc1cccc(CNC(=O)c2nc3scc(COCc4ccc(C(=O)O)cc4)c3c(=O)[nH]2)c1
InChI InChI=1S/C24H21N3O6S/c1-32-18-4-2-3-15(9-18)10-25-22(29)20-26-21(28)19-17(13-34-23(19)27-20)12-33-11-14-5-7-16(8-6-14)24(30)31/h2-9,13H,10-12H2,1H3,(H,25,29)(H,30,31)(H,26,27,28)
Molecular weight 479.12 Da
AlogP 0.0
HBond acceptors 9
HBond donors 3
Atoms 55

References

Publications

    Cross References

    canSARChEMBLBindingDBSGC Chemical Probes

    Vendors

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    Expert Reviews

    by SERP
    (on 15 May 2020 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
    by SERP
    (on 19 May 2020 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria