Chemical Probes logo
STO609 | STO609 : ATP competitive inhibitor of CAMKK1, CAMKK2
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CAMKK1
  • Ki:250 nM
  • IC 50:380 nM
CAMKK2
  • Ki:47 nM
  • IC 50:120 nM
ATP competitive
Up to 300 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
100-fold or more selective compared with CAMK1, CAMK4, CAMK2 gamma, MYLK, PRCK, and PRKACA
Selectivity Assessment Description:
STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases ...

Potency
Cellular
In Vitro

CAMKK1

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1074/jbc.M201075200

CAMKK2

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1074/jbc.M201075200

Chemical Information

Molecular Formula C19H10N2O3
SMILEs O=C(O)c1ccc2c3c1cccc3c(=O)n1c3ccccc3nc21
InChI InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24)
Molecular weight 314.07 Da
AlogP 3.2901000000000016
HBond acceptors 5
HBond donors 1
Atoms 34

References

Publications

Cross References

Expert Reviews

by SERP
(on 29 Aug 2016 )
Cellular Use Rating
( The reviewer did not leave any comments )
by SERP
(on 29 Aug 2016 )
Cellular Use Rating
( The reviewer did not leave any comments )
by SERP
(on 29 Aug 2016 )
Cellular Use Rating
( The reviewer did not leave any comments )
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria