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STK16-IN-1 | STK16-IN-1 : ATP competitive inhibitor of STK16
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
STK16
  • IC50:295 nM
  • IC50:910 nM
  • IC50:1200 nM
  • IC50:1200 nM
  • Activity:10µM
ATP competitive
up to 10 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Selectivity profiling using DiscoveRx’s KinomeScan technology proved that among the 442 kinases test ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
STK16-IN-1 did not exhibit any apparent inhibitory activity against four class I isoforms of PI3K up ...

Potency
Cellular
In Vitro

STK16

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acschembio.6b00250

Chemical Information

Molecular Formula C17H12FN3O
SMILEs Cc1cc(-n2c(=O)ccc3c[nH]c4nccc-4c32)ccc1F
InChI InChI=1S/C17H12FN3O/c1-10-8-12(3-4-14(10)18)21-15(22)5-2-11-9-20-17-13(16(11)21)6-7-19-17/h2-9H,1H3,(H,19,20)
Molecular weight 293.10 Da
AlogP 3.2661200000000017
HBond acceptors 4
HBond donors 1
Atoms 34

References

Publications

Cross References

canSARChEMBL

Vendors

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Expert Reviews

by SERP+
(on 17 Jun 2024 )
Cellular Use Rating
In an in vitro potency characterisation, STK16-IN-1 demonstrated an IC50 value of 295 nM in enzymatic assay (LifeTechnology SelectScreen). Selectivity was tested by DiscoverRx KinomeScan against 442 kinases,...
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