Chemical Probes logo
SS-208 | Inhibitor of HDAC6
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
HDAC6
  • IC50:12 nM
  • IC50:500 nM
Inhibitor
up to 5 uM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50 - HDAC1 1390 nM

Potency Assay Off-Target:
HDAC inhibition assay
Selectivity Assessment Description:
Selectivity against other HDAC isoforms (IC50, uM): HDAC4 (19.5), HDAC5 (6.91), HDAC7 (8.34), HDA ...

Potency
Cellular
In Vitro

HDAC6

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acs.jmedchem.9b00946

In Vivo Validations

Mouse
Dose: 25 mg/Kg
Route of delivery: Intraperitoneal

DOI Reference: 10.1021/acs.jmedchem.9b00946

Orthogonal Probes def

Tubacin
ACY738
Tubastatin A

Chemical Information

Molecular Formula C13H11Cl2N3O4
SMILEs O=C(NCCc1cc(C(=O)NO)no1)c1ccc(Cl)c(Cl)c1
InChI InChI=1S/C13H11Cl2N3O4/c14-9-2-1-7(5-10(9)15)12(19)16-4-3-8-6-11(18-22-8)13(20)17-21/h1-2,5-6,21H,3-4H2,(H,16,19)(H,17,20)
Molecular weight 343.01 Da
AlogP 2.0728999999999997
HBond acceptors 7
HBond donors 3
Atoms 33

References

Publications

Cross References

canSARChEMBLBindingDBPDB

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the portal.

Expert Reviews

by SERP
(on 19 Mar 2021 )
Cellular Use Rating
In Model Organisms
( The reviewer did not leave any comments )
by SERP
(on 4 May 2021 )
Cellular Use Rating
In Model Organisms
SS-208 represents a well-validated, selective chemical tool for exploring the functions of HDAC6 in cells. Notably, SS-206 does not induce cytotoxicity in human or mouse cell lines at doses where significant...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria