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SS-208 | Inhibitor of HDAC6
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

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Targets Biochemical/Biophysical Potency Cellular Potency
HDAC6
  • IC50:12 nM
  • IC50:500 nM
Inhibitor
up to 5 uM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50 - HDAC1 1390 nM

Potency Assay Off-Target:
HDAC inhibition assay
Selectivity Assessment Description:
Selectivity against other HDAC isoforms (IC50, uM): HDAC4 (19.5), HDAC5 (6.91), HDAC7 (8.34), HDA ...

Potency
Cellular
In Vitro

HDAC6

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acs.jmedchem.9b00946

In Vivo Validations

Mouse
Dose: 25 mg/Kg
Route of delivery: Intraperitoneal

DOI Reference: 10.1021/acs.jmedchem.9b00946

Orthogonal Probes def

Tubacin
ACY738
Tubastatin A

Chemical Information

Molecular Formula C13H11Cl2N3O4
SMILEs O=C(NCCc1cc(C(=O)NO)no1)c1ccc(Cl)c(Cl)c1
InChI InChI=1S/C13H11Cl2N3O4/c14-9-2-1-7(5-10(9)15)12(19)16-4-3-8-6-11(18-22-8)13(20)17-21/h1-2,5-6,21H,3-4H2,(H,16,19)(H,17,20)
Molecular weight 343.01 Da
AlogP 2.0728999999999997
HBond acceptors 7
HBond donors 3
Atoms 33

References

Publications

Cross References

canSARChEMBLBindingDBPDB

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the portal.

Expert Reviews

by SERP
(on 19 Mar 2021)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
by SERP
(on 4 May 2021)
Cellular Use Rating
In Model Organisms
SS-208 represents a well-validated, selective chemical tool for exploring the functions of HDAC6 in cells. Notably, SS-206 does not induce cytotoxicity in human or mouse cell lines at doses where significant...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria