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SR-0813 | Inhibitor of MLLT1, MLLT3
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MLLT1
  • IC 50:25 nM
  • Kd:30 nM
  • EC 50:205 nM
MLLT3
  • IC 50:311 nM
  • EC 50:76 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Selective over YEATS2 and YEATS4. Outside target family: SR-0813 was profiled for off-target effects ...

Potency
Cellular
In Vitro

MLLT1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acscentsci.0c01550

MLLT3

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acscentsci.0c01550

Orthogonal Probes def

NVS-MLLT-1
PFI-6
SGC-iMLLT

Chemical Information

Molecular Formula C25H32N6O3S
SMILEs O=C(NC1CCC1)c1ccc2nc(-c3cccc(NS(=O)(=O)NCCN4CCCCC4)c3)cn2c1
InChI InChI=1S/C25H32N6O3S/c32-25(27-21-7-5-8-21)20-10-11-24-28-23(18-31(24)17-20)19-6-4-9-22(16-19)29-35(33,34)26-12-15-30-13-2-1-3-14-30/h4,6,9-11,16-18,21,26,29H,1-3,5,7-8,12-15H2,(H,27,32)
Molecular weight 496.23 Da
AlogP 0.0
HBond acceptors 9
HBond donors 3
Atoms 67

References

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Expert Reviews

by SERP+
(on 23 Sept 2024 )
Cellular Use Rating
( The reviewer did not leave any comments )
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria