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Sotuletinib | Sotuletinib : Inhibitor of CSF1R
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CSF1R
  • IC50:1 nM
  • EC50:67 nM
  • Activity:67 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Invitrogen Kinase profiling (30 kinases)shows a > 3000 fold selectivity against KIT

Potency
Cellular
In Vitro

CSF1R

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1038/nm.3337

In Vivo Validations

Mouse
Dose: 200 mg/Kg
Route of delivery: Oral
Organ of interest (O): brain
Target engagement assay: compound is brain penentrant

DOI Reference: 10.4161/onci.26968

Orthogonal Probes def

Vimseltinib
PEXIDARTINIB

Chemical Information

Molecular Formula C20H22N4O3S
SMILEs CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1
InChI InChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24)/t14-,17-/m1/s1
Molecular weight 398.14 Da
AlogP 3.558600000000002
HBond acceptors 7
HBond donors 3
Atoms 50

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Expert Reviews

No SERP comments found for Sotuletinib

Probe Sotuletinib is in the process of SERP review.

Please continue to check back for new reviews and commentary.