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SN-011 | SN-011 : Inhibitor of STING1
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
STING1
  • Kd:4.03 nM
  • IC50:127.5 nM
  • IC50:107.1 nM
  • IC50:502.8 nM
  • IC50:76 nM
  • INH:1 µM
Inhibitor
up to 1 uM

Selectivity

In Cell Selectivity Assessment
Selectivity Assessment Description:
No effect on IRF3 and NF-κB–responsive gene expression upon SN-011 treatment in MEFs.
In Vitro Selectivity Assessment
Selectivity Assessment Description:
A biotinylated SN-011 derivative (SN-012) pulled down STING, but not other components of the STING p ...

Potency
Cellular
In Vitro

STING1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1073/pnas.2105465118

In Vivo Validations

Mouse
Dose: 5 mg/Kg
Route of delivery: Intraperitoneal

DOI Reference: 10.1073/pnas.2105465118

Negative Control Compounds

CANSAR3935388
Notes: SN-100 had no effect on the phosphorylation of TBK1, IRF3, IκBα, and p65, as well as IRF3 dimerization and IRF3 and p65 nuclear translocation

Chemical Information

Molecular Formula C25H19FN2O4S
SMILEs O=C(Nc1ccc(O)c(NS(=O)(=O)c2ccc(F)cc2)c1)c1ccc(-c2ccccc2)cc1
InChI InChI=1S/C25H19FN2O4S/c26-20-10-13-22(14-11-20)33(31,32)28-23-16-21(12-15-24(23)29)27-25(30)19-8-6-18(7-9-19)17-4-2-1-3-5-17/h1-16,28-29H,(H,27,30)
Molecular weight 462.10 Da
AlogP 0.0
HBond acceptors 6
HBond donors 3
Atoms 52

References

Publications

Cross References

canSARChEMBLBindingDB

Vendors

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Expert Reviews

by SERP
(on 16 Jul 2024 )
Cellular Use Rating
In Model Organisms
( The reviewer did not leave any comments )
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