SJ6986 |
SJ6986 : Molecular Glue of GSPT1, GSPT2
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| GSPT1 |
| |
| GSPT2 |
|
Molecular Glues
up to 100 nM
Selectivity
In Cell Selectivity Assessment
Potency Assay Off-Target:
Proteome-wide selectivity was assessed performing multiplexed mass spectrometry-based proteomic anal ...
Potency Cellular
In Vitro
GSPT1
Mode of Action: Molecular Glues
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acs.jmedchem.0c01313
GSPT2
Mode of Action: Molecular Glues
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acs.jmedchem.0c01313
In Vivo Validations
Mouse
Dose: 3 mg/Kg
Route of delivery:
Intravenous
Plasma half life:
3.44 h
Systemic clearance:
0.46 mL/min/Kg
Cmax:
47.16 ug/mL
Area Under the Curve::
107.28 h*ug/mL
Volume of Distribution at Steady-State:
0.15 L/Kg
DOI Reference: 10.1021/acs.jmedchem.0c01313
Dose: 10 mg/Kg
Route of delivery:
Oral
Cmax:
31.66 ug/mL
Tmax:
0.25 h
Area Under the Curve::
298.74 h*ug/mL
Bioavailability:
84%
DOI Reference: 10.1021/acs.jmedchem.0c01313
Dose: 1 mg/Kg
Route of delivery:
Oral
Plasma half life:
11.7 h
Cmax:
5.3 uM
Tmax:
4 h
DOI Reference: 10.1182/blood.2022017813
Dose: 3 mg/Kg
Route of delivery:
Oral
Plasma half life:
9.6 h
Cmax:
15.3 uM
Tmax:
2 h
DOI Reference: 10.1182/blood.2022017813
Chemical Information
| Molecular Formula | C20H14F3N3O7S |
| InChI | InChI=1S/C20H14F3N3O7S/c21-20(22,23)33-14-3-1-2-4-15(14)34(31,32)25-10-5-6-11-12(9-10)19(30)26(18(11)29)13-7-8-16(27)24-17(13)28/h1-6,9,13,25H,7-8H2,(H,24,27,28) |
| Molecular weight | 497.05 Da |
| AlogP | 0.0 |
| HBond acceptors | 10 |
| HBond donors | 2 |
| Atoms | 48 |