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SGK1-IN-1 | SGK1-IN-1 : Inhibitor of SGK1
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
SGK1
  • IC50:1 or 41 nM
  • IC50:690 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Selectivity within target family: SGK2 128 nM SGK3 3100 nM Assessed against a panel of 60 Kinases wi ...

Potency
Cellular
In Vitro

SGK1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/ml5003376

Chemical Information

Molecular Formula C17H12ClFN6O2S
SMILEs Nc1n[nH]c2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)cnc12
InChI InChI=1S/C17H12ClFN6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24)
Molecular weight 418.04 Da
AlogP 3.195400000000001
HBond acceptors 8
HBond donors 4
Atoms 40

References

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Expert Reviews

by SERP
(on 22 Nov 2023 )
Cellular Use Rating
Compound is ATP-competitive and binds to target and displays selectivity against kinase targets and anti-targets through profiling. The compound suffers incredibly poor aqueous solubility which limits...
by SERP+
(on 17 Jun 2024 )
Cellular Use Rating
There are no available probes for SGK1 with comparably high potency. A direct target engagement is not really shown, but phosphorylation of GSK3beta has been described. The compound has only been tested...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria