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SGC-STK-17B-1 | SGC-STK-17B-1 : Inhibitor of STK17B
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
STK17B
  • Kd:34 nM
  • IC50:190 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
SGC-STK17B-1 was profiled in the KINOMEscan assay against of 403 wild-type kinases @ 1 mM, followed ...

Potency
Cellular
In Vitro

STK17B

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.0c01174

Negative Control Compounds

SGC-STK17B-1N
Notes: SGC-STK17B-1N show IC50 > 10,000 nM against STK17B in NanoBRET assay.
SMILES: O=C(O)CSC1=C2C(SC(C3=CC(C=CC=C4)=C4S3)=C2)=NC=N1

Chemical Information

Molecular Formula C16H10N2O2S3
SMILEs O=C(O)CSc1ncnc2cc(-c3cc4ccccc4s3)sc12
InChI InChI=1S/C16H10N2O2S3/c19-14(20)7-21-16-15-10(17-8-18-16)6-13(23-15)12-5-9-3-1-2-4-11(9)22-12/h1-6,8H,7H2,(H,19,20)
Molecular weight 357.99 Da
AlogP 4.749700000000002
HBond acceptors 4
HBond donors 1
Atoms 33

Vendors

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Expert Reviews

by SERP
(on 19 Jun 2022)
Cellular Use Rating
The availability of a highly similar, but inactive, analog is a big plus for this probe. Although 1uM is probably safe, I would recommend starting lower than 1uM. The NanoBRET IC50 for CAMKK2 is 2.4uM,...
by SERP
(on 24 Aug 2022)
Cellular Use Rating
This probe appears to have exquisite selectivity for STK17B and is appropriate for use in cell-based studies. It has some off-target effects on CAMKK2 and CAMKK1, but the apparent Kd for these off-targets...
by SERP+
(on 23 May 2024)
Cellular Use Rating
This compound is recommended as a chemical probe. It is well characterised in vitro (KinaseSeeker) and in cell (NanoBRET). It also has all structural data.
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria