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SGC-STK-17B-1 | SGC-STK-17B-1 : Inhibitor of STK17B
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
STK17B
  • Kd:34 nM
  • IC50:190 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
SGC-STK17B-1 was profiled in the KINOMEscan assay against of 403 wild-type kinases @ 1 mM, followed ...

Potency
Cellular
In Vitro

STK17B

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.0c01174

Negative Control Compounds

SGC-STK17B-1N
Notes: SGC-STK17B-1N show IC50 > 10,000 nM against STK17B in NanoBRET assay.
SMILES: O=C(O)CSC1=C2C(SC(C3=CC(C=CC=C4)=C4S3)=C2)=NC=N1

Chemical Information

Molecular Formula C16H10N2O2S3
SMILEs O=C(O)CSc1ncnc2cc(-c3cc4ccccc4s3)sc12
InChI InChI=1S/C16H10N2O2S3/c19-14(20)7-21-16-15-10(17-8-18-16)6-13(23-15)12-5-9-3-1-2-4-11(9)22-12/h1-6,8H,7H2,(H,19,20)
Molecular weight 357.99 Da
AlogP 4.749700000000002
HBond acceptors 4
HBond donors 1
Atoms 33

Vendors

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Expert Reviews

by SERP
(on 19 Jun 2022 )
Cellular Use Rating
The availability of a highly similar, but inactive, analog is a big plus for this probe. Although 1uM is probably safe, I would recommend starting lower than 1uM. The NanoBRET IC50 for CAMKK2 is 2.4uM,...
by SERP
(on 24 Aug 2022 )
Cellular Use Rating
This probe appears to have exquisite selectivity for STK17B and is appropriate for use in cell-based studies. It has some off-target effects on CAMKK2 and CAMKK1, but the apparent Kd for these off-targets...
by SERP+
(on 23 May 2024 )
Cellular Use Rating
This compound is recommended as a chemical probe. It is well characterised in vitro (KinaseSeeker) and in cell (NanoBRET). It also has all structural data.
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria