SGC-PI5P4Kg/MYLK-1 |
SGC-PI5P4Kg/MYLK-1 : Inhibitor of PIP4K2C, MYLK4
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download
Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| PIP4K2C |
|
|
| MYLK4 |
|
|
Inhibitor
500 nM
up to 1 uM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
SGC-PI5P4Kγ/MYLK4-1 was profiled in the DiscoverX scanMAX assay against 403 wild-type kinases at 1 μ ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
NanoBRET analysis of cellular binding affinity for PIKfyve (NB IC50 = 450 nM), CLK2 (NB IC50 = ...
Potency Cellular
In Vitro
PIP4K2C
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1016/j.crchbi.2022.100036
MYLK4
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1016/j.crchbi.2022.100036
Negative Control Compounds
SGC-PI5P4Kγ/MYLK4-1N
Notes: cpd 4 shows enzymatic Kd 6400 nM and NanoBRET IC50 >10000 nM
SMILES:
NC1=NC2=C(CCCCC3=C2C4=C(C=CC(C#CC5CC5)=C4)N3)C=N1
Chemical Information
| Molecular Formula | C20H20N4O |
| SMILEs | Nc1ncc2c(n1)-c1c([nH]c3ccc(C4=CCOCC4)cc13)CCC2 |
| InChI | InChI=1S/C20H20N4O/c21-20-22-11-14-2-1-3-17-18(19(14)24-20)15-10-13(4-5-16(15)23-17)12-6-8-25-9-7-12/h4-6,10-11,23H,1-3,7-9H2,(H2,21,22,24) |
| Molecular weight | 332.16 Da |
| AlogP | 0.0 |
| HBond acceptors | 5 |
| HBond donors | 3 |
| Atoms | 45 |