SGC-GSK3-1 |
SGC-GSK3-1 : Inhibitor of GSK3A and GSK3B
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| GSK3A |
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| GSK3B |
|
|
Inhibitor
up to 1 uM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
SGC-GSK3-1 was analyzed at 1 μM in the Eurofins DiscoverX scanMAX panel (403 wild-type (WT) human as ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
200-fold selectivity window is observed between GSK3β and DYRK1B when comparing NanoBRET cellular ta ...
Potency Cellular
In Vitro
GSK3A
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acschemneuro.3c00135
GSK3B
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? No
DOI Reference: 10.1021/acschemneuro.3c00135
Orthogonal Probes def
SGC-CDKL5/GSK3-1
SMILES:
O=C(C1=NNC=C1NC(C2=CC(F)=CC(F)=C2)=O)NC3CCNCC3
Chemical Information
| Molecular Formula | C17H18F2N4O3 |
| SMILEs | O=C(NCC1CCOCC1)c1n[nH]cc1NC(=O)c1c(F)cccc1F |
| InChI | InChI=1S/C17H18F2N4O3/c18-11-2-1-3-12(19)14(11)16(24)22-13-9-21-23-15(13)17(25)20-8-10-4-6-26-7-5-10/h1-3,9-10H,4-8H2,(H,20,25)(H,21,23)(H,22,24) |
| Molecular weight | 364.13 Da |
| AlogP | 0.0 |
| HBond acceptors | 7 |
| HBond donors | 3 |
| Atoms | 44 |