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SecinH3 | Inhibitor of CYTH1, CYTH3, CYTH2
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CYTH1
  • Kd:200 nM
  • IC50:2200 nM
CYTH3
  • Kd:239 nM
    CYTH2
    • Kd:250 nM
      Inhibitor
      up to 15 uM

      Selectivity

      In Vitro Selectivity Assessment
      Selectivity Assessment Description:
      The Sec7 domain of EFA6, an ARF6-GEF that does not belong to the cytohesin family, was bound about 3 ...

      Potency
      Cellular
      In Vitro

      CYTH1

      Mode of Action: Inhibitor

      Structure-Activity-Relationship data available? Yes

      DOI Reference: 10.1038/nature05415

      CYTH3

      Mode of Action: Inhibitor

      Structure-Activity-Relationship data available? Yes

      DOI Reference: 10.1038/nature05415

      CYTH2

      Mode of Action: Inhibitor

      Structure-Activity-Relationship data available? Yes

      DOI Reference: 10.1038/nature05415

      Negative Control Compounds

      D5
      Notes: SecinD5 is inactive in the aptamer displacement and GDP/GTP exchange assays

      Chemical Information

      Molecular Formula C24H20N4O4S
      SMILEs COc1nc(-c2ccc3c(c2)OCO3)n(-c2ccc(NC(=O)CSc3ccccc3)cc2)n1
      InChI InChI=1S/C24H20N4O4S/c1-30-24-26-23(16-7-12-20-21(13-16)32-15-31-20)28(27-24)18-10-8-17(9-11-18)25-22(29)14-33-19-5-3-2-4-6-19/h2-13H,14-15H2,1H3,(H,25,29)
      Molecular weight 460.12 Da
      AlogP 0.0
      HBond acceptors 8
      HBond donors 1
      Atoms 53

      Vendors

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      Expert Reviews

      No SERP comments found for SecinH3

      Probe SecinH3 is in the process of SERP review.

      Please continue to check back for new reviews and commentary.