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SCH772984 | SCH772984 : ATP competitive inhibitor of MAPK1, MAPK3
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MAPK1
  • IC 50:4 nM
  • EC 50:<500 nM
MAPK3
  • Kd:0.24 nM
  • IC 50:1 nM
  • EC 50:<500 nM
ATP competitive
10 nM - 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Only 6 off-target kinases showed >50% inhibition at 1 uM (CLK2, FLT4, GSG2, MAP4K4, MINK1, PRKD1, TT ...
Selectivity Assessment Description:
Only 6 off-target kinases showed >50% inhibition at 1 uM (CLK2, FLT4, GSG2, MAP4K4, MINK1, PRKD1, TT ...

Potency
Cellular
In Vitro

MAPK1

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1158/2159-8290.CD-13-0070

MAPK3

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1158/2159-8290.CD-13-0070

Chemical Information

Molecular Formula C33H33N9O2
SMILEs O=C(Nc1ccc2[nH]nc(-c3ccncc3)c2c1)[C@@H]1CCN(CC(=O)N2CCN(c3ccc(-c4ncccn4)cc3)CC2)C1
InChI InChI=1S/C33H33N9O2/c43-30(42-18-16-41(17-19-42)27-5-2-24(3-6-27)32-35-11-1-12-36-32)22-40-15-10-25(21-40)33(44)37-26-4-7-29-28(20-26)31(39-38-29)23-8-13-34-14-9-23/h1-9,11-14,20,25H,10,15-19,21-22H2,(H,37,44)(H,38,39)/t25-/m1/s1
Molecular weight 587.28 Da
AlogP 3.6911
HBond acceptors 11
HBond donors 2
Atoms 77

Vendors

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Expert Reviews

by SERP
(on 1 Jun 2016 )
Cellular Use Rating
In Model Organisms
SCH772984 inhibits ERK protein kinase with a nanomolar IC50 in vitro (1 nM for ERK2, and 4 nM for ERK4) while being much less potent against MEK1 (IC50 >10 uM). At 1 uM, this probe also inhibits the...
by SERP
(on 10 Jun 2016 )
Cellular Use Rating
In Model Organisms
SCH772984 is an extremely selective ERK1/2 inhibitor and effectively suppresses MAPK pathway signaling and cell proliferation in BRAF, MEK, and BRAF​/MEK inhibitor-​resistant tumor models. In vitro...
by SERP
(on 9 Sept 2016 )
Cellular Use Rating
In Model Organisms
SCH772984 is a potent inhibitor of ERK1 and ERK2, with very high selectivity over other kinases, especially when used at concentrations below 1 micromolar. Strong on-target inhibition of ERK signalling...
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