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SC-560 | Inhibitor of PTGS1
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
PTGS1
  • IC50:9 nM
    Inhibitor
    300 nM

    Selectivity

    In Vitro Selectivity Assessment
    Selectivity Assessment Description:
    Selective against COX-2 with IC50 6.3 μM and more than 40% of remaining COX-2 activity at concent ...

    Potency
    Cellular
    In Vitro

    PTGS1

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1073/pnas.95.22.13313

    In Vivo Validations

    Rat
    Dose: 10 mg/Kg
    Route of delivery: Intravenous
    Plasma half life: 5.4 ± 0.8 h
    Systemic clearance: 1.15 ± 0.46 L/h/kg
    Area Under the Curve:: 9704 ± 4038 ng h/mL
    Volume of Distribution at Steady-State: 9.1 ± 4.6 L/kg
    Target engagement assay: Oral dosing with either 10 or 30 mg/kg SC-560 1 hr before assay completely inhibited ionophore-stimulated TxB2 production in ex vivo assay

    PMID Reference: 12935431

    Dose: 10 mg/Kg
    Route of delivery: Oral
    Plasma half life: 3.7 ± 1.6 (PEG) and 2.7 ± 1.7 (MC) h
    Cmax: 218.5 ± 86.9 (PEG) and 119.8 ± 15.5 (MC) ng/mL
    Tmax: 1.00 ± 1.8 (PEG) and 2.0 ± 0 (MC) h
    Area Under the Curve:: 1203.4 ± 130.3 (PEG) and 523 ± 208 (MC) ng*h/mL

    PMID Reference: 12935431

    Negative Control Compounds

    CELECOXIB
    Notes: IC50 15uM in biochemical assay (40 nM for COX-2)

    Chemical Information

    Molecular Formula C17H12ClF3N2O
    SMILEs COc1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(Cl)cc2)cc1
    InChI InChI=1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
    Molecular weight 352.06 Da
    AlogP 5.220100000000003
    HBond acceptors 3
    HBond donors --
    Atoms 36

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    Expert Reviews

    by SERP
    (on 2 Jan 2023 )
    Cellular Use Rating
    In Model Organisms
    This is for sure a very suitable COX probe.
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria