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SB-714786 | SB-714786 : Antagonist of HTR1D
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
HTR1D
  • Ki:0.8 nM
Antagonist
100 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
In Vitro cross-screening characterization against cloned human receptors: 5-HT1E, 1F, 2A, 2B, 2C, 4, ...

Potency
Cellular
In Vitro

HTR1D

Mode of Action: Antagonist

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/jm049039v

Negative Control Compounds

CANSAR149525
Notes: cpd 8 pKi <5

Chemical Information

Molecular Formula C26H28N4O
SMILEs Cc1ccc2c(OCCN3CCN(Cc4cccc5cccnc45)CC3)cccc2n1
InChI InChI=1S/C26H28N4O/c1-20-10-11-23-24(28-20)8-3-9-25(23)31-18-17-29-13-15-30(16-14-29)19-22-6-2-5-21-7-4-12-27-26(21)22/h2-12H,13-19H2,1H3
Molecular weight 412.23 Da
AlogP 0.0
HBond acceptors 5
HBond donors --
Atoms 59

References

Publications

Cross References

canSARChEMBLBindingDB

Vendors

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Expert Reviews

by SERP
(on 16 Aug 2022 )
Cellular Use Rating
( The reviewer did not leave any comments )
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria