Chemical Probes logo
SB-714786 | SB-714786 : Antagonist of HTR1D
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
HTR1D
  • Ki:0.8 nM
Antagonist
100 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
In Vitro cross-screening characterization against cloned human receptors: 5-HT1E, 1F, 2A, 2B, 2C, 4, ...

Potency
Cellular
In Vitro

HTR1D

Mode of Action: Antagonist

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/jm049039v

Negative Control Compounds

cpd 8
Notes: cpd 8 pKi <5

Chemical Information

Molecular Formula C26H28N4O
SMILEs Cc1ccc2c(OCCN3CCN(Cc4cccc5cccnc45)CC3)cccc2n1
InChI InChI=1S/C26H28N4O/c1-20-10-11-23-24(28-20)8-3-9-25(23)31-18-17-29-13-15-30(16-14-29)19-22-6-2-5-21-7-4-12-27-26(21)22/h2-12H,13-19H2,1H3
Molecular weight 412.23 Da
AlogP 0.0
HBond acceptors 5
HBond donors --
Atoms 59

References

Publications

Cross References

canSARChEMBLBindingDB

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the portal.

Expert Reviews

by SERP
(on 16 Aug 2022)
Cellular Use Rating
(The reviewer did not leave any public comments)
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria