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RW-78 | RW-78 : Inhibitor of SIRT2
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
SIRT2
  • IC50:26 nM
  • EC50:15 nM
Inhibitor
1 µM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Subtype selective towards SIRT2. IC50 values for SIRT1, 3 and 5 are above 50 µM

Potency
Cellular
In Vitro

SIRT2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1039/D5MD00144G

Chemical Information

Molecular Formula C26H25ClN6O3S
SMILEs Cc1cc(C)nc(SCC(=O)Nc2cccc(COc3ccc(NC(=O)c4cnn(C)c4)c(Cl)c3)c2)n1
InChI InChI=1S/C26H25ClN6O3S/c1-16-9-17(2)30-26(29-16)37-15-24(34)31-20-6-4-5-18(10-20)14-36-21-7-8-23(22(27)11-21)32-25(35)19-12-28-33(3)13-19/h4-13H,14-15H2,1-3H3,(H,31,34)(H,32,35)
Molecular weight 536.14 Da
AlogP 5.042440000000004
HBond acceptors 9
HBond donors 2
Atoms 62

Expert Reviews

by SERP
(on 23 Feb 2026 )
Cellular Use Rating
RW-78 is a potent and subtype selective SIRT2 probe that displaces the NAD+ co-factor. It showed high target engagement in HEK293T cells via NanoBRET assay. Solubility: > 50 μM (Tris-HCl, pH = 8, final...
by SERP
(on 9 Mar 2026 )
Cellular Use Rating
RW-78 is a potent SIRT2 inhibitor (cell-free IC50 = 26 nM) with reported selectivity over SIRT1, SIRT3, and SIRT5. Cellular target engagement in HEK293T cells was demonstrated using a BRET assay (IC50...
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