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RUSKI-201 | Inhibitor of HHAT
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
HHAT
  • 0.2 uM:IC50
  • IC50:0.73 uM
Inhibitor
up to 10 uM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
RUSKI-201 did not inhibit reporter signal in several Shh-pathway independent assays of a Gli-reporte ...

Potency
Cellular
In Vitro

HHAT

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

Chemical Information

Molecular Formula C20H27N3OS
SMILEs CCC(C)CNCC(=O)N1CCc2sccc2C1c1cccc(C)n1
InChI InChI=1S/C20H27N3OS/c1-4-14(2)12-21-13-19(24)23-10-8-18-16(9-11-25-18)20(23)17-7-5-6-15(3)22-17/h5-7,9,11,14,20-21H,4,8,10,12-13H2,1-3H3
Molecular weight 357.19 Da
AlogP 3.561320000000003
HBond acceptors 4
HBond donors 1
Atoms 52

References

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    Vendors

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    Expert Reviews

    by SERP
    (on 28 Aug 2020 )
    Cellular Use Rating
    Users should note the following limitations: (1) there is still limited SAR reported surrounding the RU-SKI series (e.g., there is no inactive control analog suggested that I am aware of), (2) this...
    by SERP
    (on 5 Sept 2020 )
    Cellular Use Rating
    Users of this compound should be aware that this is a diastereoisomeric mixture besides a conformational mixture of E and Z amide. The invitro and in cell data are produced on this mixture.
    by SERP
    (on 12 Oct 2020 )
    Cellular Use Rating
    ( The reviewer did not leave any comments )
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria