RIMEGEPANT |
RIMEGEPANT : Antagonist of CRCP
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| CRCP |
|
|
Antagonist
up to 100 nM
Selectivity
In Vitro Selectivity Assessment
AMY1A
Gene ID: P0DUB6
Organism: Homo sapiens
Family: glycosyl hydrolase 13 family
Potency: IC50 - 170 nM
Potency Assay Off-Target:
BMS-927711 exhibited no significant off-target liabilities when tested against a range of 45 recepto ...
Selectivity Assessment Description:
Rimegepant completely blocked activation of the CGRP and AMY1 receptors but was approximately 17-fol ...
Potency Cellular
In Vitro
CRCP
Mode of Action: Antagonist
Structure-Activity-Relationship data available? No
DOI Reference: 10.1021/jm3013147
In Vivo Validations
Rat
Monkey (Cynomolgus)
Chemical Information
| Molecular Formula | C28H28F2N6O3 |
| InChI | InChI=1S/C28H28F2N6O3/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37)/t18-,22+,24-/m0/s1 |
| Molecular weight | 534.22 Da |
| AlogP | 0.0 |
| HBond acceptors | 9 |
| HBond donors | 3 |
| Atoms | 67 |