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Rentosertib | Rentosertib : Inhibitor of TNIK
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
TNIK
  • IC50:31 nM
  • Kd:4.3 nM
  • IC50:14.7 nM
  • IC50:7.8 nM
  • IC50:63 nM
  • IC50:27 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Rentosertib was profiled in an off-target panel of 78 proteins, including GPCRs, nuclear receptors, ...
In Vitro Selectivity Assessment
Potency Assay Off-Target:
Rentosertib was screened at the dose of 10 μM against a panel of 430 enzymes, which consists of both ...

Potency
Cellular
In Vitro

TNIK

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.4c01580

In Vivo Validations

Mouse
Dose: 3 mg/Kg
Route of delivery: Intravenous
Plasma half life: 1.22 h
Systemic clearance: 123.5 mL/min/kg
Area Under the Curve:: 403 ng·h/mL
Volume of Distribution at Steady-State: 4650 mL/kg

DOI Reference: 10.1021/acs.jmedchem.4c01580

Dose: 30 mg/Kg
Route of delivery: Oral
Cmax: 1010 ng/mL
Tmax: 0.25 h
Area Under the Curve:: 1770 ng·h/mL
Bioavailability: 44%

DOI Reference: 10.1021/acs.jmedchem.4c01580

Dog
Dose: 1 mg/Kg
Route of delivery: Intravenous
Plasma half life: 1.65 h
Systemic clearance: 32.2 mL/min/kg
Area Under the Curve:: 512 ng·h/mL
Volume of Distribution at Steady-State: 2031.3 mL/kg

DOI Reference: 10.1021/acs.jmedchem.4c01580

Dose: 10 mg/Kg
Route of delivery: Oral
Cmax: 536 ng/mL
Tmax: 0.708 h
Area Under the Curve:: 1120 ng·h/mL
Bioavailability: 22%

DOI Reference: 10.1021/acs.jmedchem.4c01580

Chemical Information

Molecular Formula C27H30FN7O
SMILEs CC(C)n1cnc(-c2ccc(F)cc2)c1-c1ncc(C(=O)Nc2ccc(N3CCN(C)CC3)cc2)[nH]1
InChI InChI=1S/C27H30FN7O/c1-18(2)35-17-30-24(19-4-6-20(28)7-5-19)25(35)26-29-16-23(32-26)27(36)31-21-8-10-22(11-9-21)34-14-12-33(3)13-15-34/h4-11,16-18H,12-15H2,1-3H3,(H,29,32)(H,31,36)
Molecular weight 487.25 Da
AlogP 4.664300000000003
HBond acceptors 8
HBond donors 2
Atoms 66
PAINS * Yes

* This is an automated alert only, and may not necessarily indicate an issue with this probe. ( Learn more about PAINS )

References

Publications

Cross References

canSAR

Expert Reviews

by SERP
(on 19 Dec 2025 )
Cellular Use Rating
In Model Organisms
Compound 4 (rentosertib) is a potent TNIK kinase inhibitor with an IC50 of 7.8nM in a radiometric assay and a Kd of 4.3nM as measured by SPR. However, there are no published direct target engagement data....
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