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(R)-Zinc-3573 | Agonist of MRGPRX2
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

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Targets Biochemical/Biophysical Potency Cellular Potency
MRGPRX2
    • EC50:740 nM
    • EC50:1000 nM
    Agonist
    up to 1 uM

    Selectivity

    In Cell Selectivity Assessment
    Selectivity Assessment Description:
    315 GPCRs were screened at 10uM. Potential hits were re-screened by dose response. Two off-target ...

    Potency
    Cellular
    In Vitro

    MRGPRX2

    Mode of Action: Agonist

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1038/nchembio.2334

    Negative Control Compounds

    ZINC72453574

    Chemical Information

    Molecular Formula C18H21N5
    SMILEs CN(C)[C@@H]1CCN(c2cc(-c3ccccc3)nc3ccnn23)C1
    InChI InChI=1S/C18H21N5/c1-21(2)15-9-11-22(13-15)18-12-16(14-6-4-3-5-7-14)20-17-8-10-19-23(17)18/h3-8,10,12,15H,9,11,13H2,1-2H3/t15-/m1/s1
    Molecular weight 307.18 Da
    AlogP 2.536600000000001
    HBond acceptors 5
    HBond donors --
    Atoms 44

    Vendors

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    Expert Reviews

    by SERP
    (on 19 May 2020)
    Cellular Use Rating
    This probe was identified through an innovative approach to first screen a set of compounds using PRESTO-Tango, then using these results to refine a structural model that could be used for subsequent...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria