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QC6352 | Inhibitor of KDM4C
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
KDM4C
  • IC50:35 ± 8 nM
  • EC50:3.5 ± 1 nM
  • EC50:1.3 ± 0.3 nM
Inhibitor
up to 100 nM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50 - KDM4B 56 ± 6 nM, KDM4D 104 ± 18 nM, KDM4A 104 ± 10nM

Selectivity Assessment Description:
Enzymatic activity (IC50 nM) KDM2B >4,000; KDM4C 35 ± 8; KDM3A >4,000; KDM4D 104 ± 18; KDM3B >4,00 ...
In Cell Selectivity Assessment
Selectivity Assessment Description:
IMR-90 EC50 >30 uM

Potency
Cellular
In Vitro

KDM4C

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acsmedchemlett.7b00220

In Vivo Validations

Mouse
Dose: 5 , 10, 25, 50 mg/Kg
Route of delivery: Intravenous, Oral
Systemic clearance: 6.9 mL/min/kg (IV)

DOI Reference: 10.1021/acsmedchemlett.7b00220

Chemical Information

Molecular Formula C24H25N3O2
SMILEs CN(c1ccccc1)c1ccc2c(c1)CCC[C@H]2CNc1cnccc1C(=O)O
InChI InChI=1S/C24H25N3O2/c1-27(19-8-3-2-4-9-19)20-10-11-21-17(14-20)6-5-7-18(21)15-26-23-16-25-13-12-22(23)24(28)29/h2-4,8-14,16,18,26H,5-7,15H2,1H3,(H,28,29)/t18-/m0/s1
Molecular weight 387.19 Da
AlogP 5.079700000000004
HBond acceptors 5
HBond donors 2
Atoms 54

References

Publications

Cross References

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Expert Reviews

by SERP
(on 14 Dec 2020 )
Cellular Use Rating
In Model Organisms
The compound represents an important advancement in the field, as it is a potent and selective probe molecule appropriate for both in vitro and in vivo work. Compound shows potent antiproliferative...
by SERP
(on 14 Dec 2020 )
Cellular Use Rating
In Model Organisms
( The reviewer did not leave any comments )
by SERP
(on 18 Dec 2020 )
Cellular Use Rating
In Model Organisms
QC6352 is a chemical probe that inhibits KDM4 family members (KDM4A, KDM4B, KDM4C, and KDM4D) with good specificity within the Jumonji demethylase family. It has been characterised in cancer cell lines...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria