PSFL1911

PSFL1911 : Negative Allosteric Modulator of P2RX7

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(0 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe PSFL1911 is in the process of SERP review.

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Information

P2RX7

Negative Allosteric Modulator

up to 1 uM

In Vitro Validations

Uniprot ID: Q99572

Target Class: Ion Channel

Target SubClass: P2X Family

PDB ID for probe-target interaction (3D structure): 8Z1D

Target aliases:

P2X purinoceptor 7, P2RX7, P2RX7_HUMAN, P2X7, Puri ...

DOI Reference: 10.1038/s41467-025-65847-0

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): When tested against other P2X receptor subtypes, PSFL1191 showed inhibition rates of -8.35 ± 4.49% for hP2X1, 3.09 ± 7.46% for hP2X2, 20.6 ± 6.4% for hP2X3, and -17.6 ± 9.0% for hP2X4 at 30 μM highlighting PSFL1191’s selectivity for P2X7 receptors.

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SERP ratings and comments

SERP Ratings

In Cell Rating

SERP Comments:

Looks a useful probe but, as ever, independent corroboration of the direct binding activity against the human target would be valuable. Structure not yet in PubChem but this should eventually be submitted via the PDB ligand structure

(last updated: 7 Jan 2026 )

SERP Ratings

In Cell Rating

SERP Comments:

PSFL1191 has the potential to be a useful chemical probe. Further data on extensive selectivity screening as well as confirmation of the data by a second lab is needed. Enantiomeric purity has to be described (ee>95).

(last updated: 30 Jan 2026 )