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PSFL1911 | PSFL1911 : Negative Allosteric Modulator of P2RX7
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
P2RX7
  • Activity:reduced activity
  • IC50:278 nM
Negative Allosteric Modulator
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
When tested against other P2X receptor subtypes, PSFL1191 showed inhibition rates of -8.35 ± 4.49% f ...

Potency
Cellular
In Vitro

P2RX7

Mode of Action: Negative Allosteric Modulator

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1038/s41467-025-65847-0

Negative Control Compounds

canSAR7437561
Notes: PSFL1190 shows an affinity for P2X7 of 12.6 ± 2.9 μM (IC50)

Chemical Information

Molecular Formula C23H25NO4
SMILEs C=CC[C@@H]1c2cc(OC)c(OC)cc2CN2CCc3cc4c(cc3[C@H]12)OCO4
InChI InChI=1S/C23H25NO4/c1-4-5-16-17-10-20(26-3)19(25-2)9-15(17)12-24-7-6-14-8-21-22(28-13-27-21)11-18(14)23(16)24/h4,8-11,16,23H,1,5-7,12-13H2,2-3H3/t16-,23+/m1/s1
Molecular weight 379.18 Da
AlogP 4.205200000000003
HBond acceptors 5
HBond donors --
Atoms 53

References

Publications

Cross References

Expert Reviews

by SERP
(on 7 Jan 2026 )
Cellular Use Rating
Looks a useful probe but, as ever, independent corroboration of the direct binding activity against the human target would be valuable. Structure not yet in PubChem but this should eventually be submitted...
by SERP
(on 30 Jan 2026 )
Cellular Use Rating
PSFL1191 has the potential to be a useful chemical probe. Further data on extensive selectivity screening as well as confirmation of the data by a second lab is needed. Enantiomeric purity has to be described...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria