PSFL1911

PSFL1911 : Negative Allosteric Modulator of P2RX7

Structure

SERP Rating

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Information

P2RX7

Negative Allosteric Modulator

up to 1 uM

In Vitro Validations

Uniprot ID: Q99572

Target Class: Ion Channel

Target SubClass: P2X Family

PDB ID for probe-target interaction (3D structure): 8Z1D

Target aliases:

P2X purinoceptor 7, P2RX7, P2RX7_HUMAN, P2X7, Puri ...

DOI Reference: 10.1038/s41467-025-65847-0

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): When tested against other P2X receptor subtypes, PSFL1191 showed inhibition rates of -8.35 ± 4.49% for hP2X1, 3.09 ± 7.46% for hP2X2, 20.6 ± 6.4% for hP2X3, and -17.6 ± 9.0% for hP2X4 at 30 μM highlighting PSFL1191’s selectivity for P2X7 receptors.

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