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Prednisolone | Prednisolone : Glucocorticoid-competitive agonist of NR3C1
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
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Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NR3C1
  • Ki:2.5 nM
  • EC50:110 nM
  • IC50:40 nM
Agonist
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Selectivity

Potency
Cellular
In Vitro

NR3C1

Mode of Action: Agonist

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/jm010228c

Chemical Information

Molecular Formula C21H28O5
SMILEs C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO
InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
Molecular weight 360.19 Da
AlogP 1.5575999999999999
HBond acceptors 5
HBond donors 3
Atoms 54

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Expert Reviews

by SERP
(on 18 Jun 2024 )
Cellular Use Rating
No solubility data No stability data No cytotoxicity data
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