PRALSETINIB |
PRALSETINIB : Inhibitor of RET
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download
Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| RET (Mutant:WT, V804M, M918T) |
|
|
Inhibitor
up to 1 uM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
BLU-667 was profiled against a panel of 106 kinases at Reaction biology. Kinase activity data were e ...
Potency Cellular
In Vitro
RET
(Mutant:WT, V804M, M918T)
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1016/j.bmcl.2021.128149
In Vivo Validations
Mouse
Dose: 10 mg/Kg
Route of delivery:
Oral
Systemic clearance:
5.0 mL/kg/min
Area Under the Curve::
46,062 nM*h
Bioavailability:
77.2%
Volume of Distribution at Steady-State:
0.7 L/Kg
DOI Reference: 10.1016/j.bmcl.2021.128149
Chemical Information
| Molecular Formula | C27H32FN9O2 |
| SMILEs | CO[C@]1(C(=O)N[C@@H](C)c2ccc(-n3cc(F)cn3)nc2)CC[C@H](c2nc(C)cc(Nc3cc(C)[nH]n3)n2)CC1 |
| InChI | InChI=1S/C27H32FN9O2/c1-16-11-22(33-23-12-17(2)35-36-23)34-25(31-16)19-7-9-27(39-4,10-8-19)26(38)32-18(3)20-5-6-24(29-13-20)37-15-21(28)14-30-37/h5-6,11-15,18-19H,7-10H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t18-,19-,27+/m0/s1 |
| Molecular weight | 533.27 Da |
| AlogP | 4.200140000000003 |
| HBond acceptors | 11 |
| HBond donors | 3 |
| Atoms | 71 |
Vendors
Note: This is not an exhaustive list and does not indicate endorsement by the portal.